Inter controlled the match from the start and opened the scoring in the 20th minute when Joaquin Correa picked out an unmarked Dzeko whose right-footed shot in the penalty area beat Plzen keeper Jindrich Stanek.
Inter Milan's Edin Dzeko scored one and created another as they cruised to a 2-0 victory at Viktoria Plzen in Champions League Group C on Tuesday.
Inter controlled the match from the start and opened the scoring in the 20th minute when Joaquin Correa picked out an unmarked Dzeko whose right-footed shot in the penalty area beat Plzen keeper Jindrich Stanek.
The Czech champions spent most of the game defending and faced an uphill battle after Pavel Bucha was sent off in the 61st minute for a dangerous tackle that caught Inter midfielder Nicolo Barella on the shin.
The visitors doubled their lead 10 minutes later on the counter attack when Dzeko turned provider with a clinical pass that allowed Denzel Dumfries to slot home.
Bayer Leverkusen left it late but pulled off a 2-0 win at home to Atletico Madrid on Tuesday to kick-start their Champions League campaign and ease the pressure on coach Gerardo Seoane.
The German side showed more intent to win the game than the visitors and finally found a breakthrough when Robert Andrich found the bottom corner of the net in the 84th minute after a cut-back from Jeremie Frimpong.
Dutch fullback Frimpong was a handful for Atletico when he came off the bench in the second half and also set up the second goal, taken confidently by Moussa Diaby in the 87th.
The win took Leverkusen second in Group B on three points, level with third-placed Atletico.
Leverkusen have lost four of their six Bundesliga games this season and were also beaten by Club Brugge in their Group B opener last week but this was a hugely encouraging performance for them against one of the Champions League heavyweights.